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Figure: Liver apoptosis regulation by CASP6 (Human)

id: gomodel:613aae0000000813

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This figure illustrates the regulatory pathways of liver apoptosis mediated by CASP6 (Caspase-6) in human hepatocytes. The diagram shows four key proteins from the GO-CAM model:

  1. PRKAA1 and PRKAA2 (blue) - Protein serine/threonine kinases that negatively regulate hepatocyte apoptosis (GO:1903944) by inhibiting CASP6 activity.

  2. CASP6 (green) - Cysteine-type endopeptidase (GO:0004197) that functions in hepatocyte apoptotic process (GO:0097284) and activates BID.

  3. BID (red) - Endopeptidase regulator involved in apoptotic process (GO:0043028) that promotes the release of cytochrome c from mitochondria (GO:0090200).

The pathway depicts how CASP6 activity is regulated by PRKAA1/2 kinases, and how CASP6 in turn regulates BID to promote cytochrome c release from mitochondria, ultimately contributing to the hepatocyte apoptotic process.

Feedback from AI on figure:

{"feedback":"The pathway diagram effectively illustrates liver apoptosis regulation by CASP6 in humans with excellent visual clarity. The color-coded proteins and interaction arrows make the regulatory relationships immediately apparent. Each component is clearly labeled with both protein names and their functions, while GO terms provide precise annotation of the biological processes involved. The cellular context is well represented with the hepatocyte outline and mitochondrion, enhancing the biological relevance of the illustration. The comprehensive legend aids interpretation by explaining both protein types and interaction categories, making this suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}