Figure: SP-ANN-RECQL5¶
This pathway diagram illustrates the GO-CAM model for RECQL5's role in DNA replication. Within the nucleus, RECQL5 exhibits helicase activity at the replication fork, utilizing ATP and water as inputs to produce ADP and phosphate as outputs. This activity is part of mitotic DNA-templated DNA replication. CDK1 positively regulates RECQL5's helicase activity through its kinase function. RECQL5, in turn, negatively regulates MUS81's endonuclease activity at the replication fork while positively regulating RAD51's single-stranded DNA binding in the presynaptic intermediate filament cytoskeleton. Green arrows indicate positive regulation, while red arrows with inhibition symbols represent negative regulation.
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the GO-CAM model of RECQL5's role in DNA replication with clear visualization of all components and their interactions. The molecular pathways are represented with appropriate scientific accuracy and visual clarity suitable for publication in high-impact journals like Cell or Nature. The use of color coding for different proteins and regulatory relationships enhances readability, while the added legend provides important context for interpreting the diagram. The spatial organization within the nuclear compartment effectively shows the relationship between the replication fork and the presynaptic intermediate filament cytoskeleton.","necessary_changes":null,"optional_changes":null}