Figure: KAT5 regulation of the cytoskeleton by acetylation of proteins (Human)

id: gomodel:617b481400000389

Figure: KAT5 regulation of the cytoskeleton by acetylation of proteins in human cells.

The pathway shows the molecular mechanisms controlling mitotic spindle attachment to kinetochores during cell division. CDK1 phosphorylates KAT5, which then acetylates AURKB (Aurora kinase B). Phosphorylated AURKB activates NDC80, a kinetochore adaptor protein, promoting attachment of spindle microtubules to kinetochores. This process is negatively regulated by SIRT1, which deacetylates NDC80. These opposing regulatory mechanisms ensure proper sister chromatid segregation during mitosis.

Proteins: CDK1 (orange), KAT5 (teal), AURKB (salmon), NDC80 (gold), SIRT1 (light green) Cellular structures: Kinetochores (red), Chromosomes (purple), Spindle microtubules (green), Centrosomes (blue) Modifications: P = phosphorylation, Ac = acetylation, deAc = deacetylation

Feedback from AI on figure:

{"feedback":"The drawing effectively captures the essential elements of the KAT5 regulation pathway, focusing on kinetochore-microtubule interactions during mitosis. The use of different shapes and colors helps distinguish between proteins and interactions, contributing to clarity. The arrowheads and labels clearly indicate the direction and type of regulation, aiding in understanding the sequence of events from CDK1 phosphorylating KAT5 to SIRT1 deacetylating NDC80. The improved text size for the process labels enhances readability, and the comprehensive legend provides necessary context for understanding the biological significance of each component in the pathway.","necessary_changes":null,"optional_changes":null}