Figure: KAT5 involvement in nucleotide excision repair (Human)¶
Figure 1: Diagram of KAT5 involvement in nucleotide excision repair (NER) in human cells. The pathway depicts how KAT5 acetylates ERCC4, while SIRT1 can deacetylate it, regulating its activity. ERCC4 binds to ERCC1 to form the ERCC4-ERCC1 complex, which exhibits endonuclease activity critical for DNA damage repair during NER. This regulatory pathway illustrates post-translational modification control of DNA repair machinery. KAT5 (Q92993) acts as a peptide-lysine-N-acetyltransferase, SIRT1 (Q96EB6) functions as an NAD-dependent protein lysine deacetylase, and ERCC4 (Q92889-2) serves as a single-stranded DNA endodeoxyribonuclease within the ERCC4-ERCC1 complex.
Feedback from AI on figure:
{"feedback":"This diagram effectively represents the KAT5 pathway in nucleotide excision repair with scientific accuracy and visual clarity appropriate for a journal figure. The representation uses clear protein identification with strategic color-coding and appropriate cellular compartmentalization within the nucleus. The mechanism shows how KAT5 acetylates ERCC4 while SIRT1 deacetylates it, creating regulatory control over the ERCC4-ERCC1 complex formation and its DNA repair function. The diagram includes all essential elements from the GO-CAM data while presenting them in a visually engaging format that would be suitable for publications like Nature or Cell.","necessary_changes":null,"optional_changes":"For further enhancement, space could be optimized to include molecular details of the acetylation/deacetylation sites or the structure of the DNA damage more specifically, though this is not essential for the current representation's effectiveness."}