Figure: KAT5 regulation of lipid droplet disassembly (Human)

id: gomodel:617b481400000559

Figure: KAT5 regulation of lipid droplet disassembly in human cells during glucose starvation.

During glucose starvation (GO:0042149), AMPK proteins (PRKAA1/PRKAA2) are activated and phosphorylate both KAT5 and CHKA. KAT5 acetylates CHKA, which inhibits CHKA homodimerization in the cytosol. CHKA homodimers normally enable phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis. The inhibition of CHKA homodimerization and phosphorylation by AMPK promotes CHKA relocalization to lipid droplets, where it exhibits protein tyrosine kinase activity. This lipid droplet-associated CHKA activity ultimately causes lipid droplet disassembly (GO:1905691), an essential adaptive response to metabolic stress.

Feedback from AI on figure:

{"feedback":"The final diagram effectively illustrates the complex pathway of KAT5 regulation of lipid droplet disassembly during glucose starvation. The layout clearly represents the relationship between different proteins and cellular compartments with a logical flow from stimulus to outcome. The color-coding system helps distinguish between different types of proteins and processes, while the consistent use of shapes creates visual hierarchy. The arrows with descriptive labels make the interactions and their directionality easy to understand.","necessary_changes":null,"optional_changes":null}