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Figure: KAT5 chromatin localization (Human)

id: gomodel:617b481400000672

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This diagram illustrates the KAT5 chromatin localization pathway in humans, based on GO-CAM model gomodel:617b481400000672. Two parallel pathways are shown:

  1. CDK9-mediated pathway (left): CDK9 (UniProtKB:P50750) phosphorylates KAT5 (UniProtKB:Q92993), promoting its localization to chromatin where it binds (GO:0003682) and exerts histone acetyltransferase activity (GO:0004402).

  2. VRK1-mediated pathway (right): In response to DNA damage (GO:0006974), VRK1 (UniProtKB:Q99986) phosphorylates KAT5, also promoting its chromatin binding, but specifically resulting in H4K16 acetyltransferase activity (GO:0046972).

Both pathways ultimately lead to positive regulation of transcription by RNA polymerase II (GO:0045944). The diagram depicts these processes occurring within the nucleus, where chromatin (GO:0000785) serves as the platform for KAT5's enzymatic activities. Dashed lines represent enzymatic activities, while solid lines indicate molecular interactions or relocalization events.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the KAT5 chromatin localization pathways described in the GO-CAM model. The use of colors, shapes, and spatial organization clearly communicates the two parallel pathways - one mediated by CDK9 and the other by VRK1 in response to DNA damage. The addition of a legend helps readers understand the symbols used, and the slightly larger font size for GO terms improves readability. The representation of chromatin as a wavy line and the histone acetylation process is visually intuitive and scientifically accurate.","necessary_changes":null,"optional_changes":null}