Figure: Epidermal growth factor receptor signaling pathway 1 (Mouse)¶
This figure illustrates the Epidermal Growth Factor Receptor (EGFR) signaling pathway in mouse cells. The pathway begins with pre-pro-EGF in the cytoplasm, which undergoes maturation by metallopeptidases MEP1A and ADAM10 (MGI:96963 and MGI:109548, respectively) at the plasma membrane (GO:0005886). The mature EGF ligand (MGI:95290) is released into the extracellular space (GO:0005615) where it binds to EGFR (MGI:95294), triggering the EGFR signaling cascade (GO:0007173). The diagram highlights the EGF receptor ligand maturation process (GO:0038004) that precedes receptor activation. Different protein types are represented by distinct shapes and colors as indicated in the legend.
Feedback from AI on figure:
{"feedback":"This diagram successfully illustrates the Epidermal Growth Factor Receptor signaling pathway in mouse cells with clarity and scientific accuracy. The spatial organization effectively represents the biological compartments (extracellular space, plasma membrane, and cytoplasm), while the protein interactions are depicted with clear directional flows. The improved font sizes enhance readability, and the consistent color scheme helps distinguish between different types of proteins in the pathway. The comprehensive legend provides necessary context for interpreting the diagram's elements.","necessary_changes":null,"optional_changes":null}