Figure: SP-RNF169¶
This diagram depicts the GO-CAM pathway for DNA damage response involving DYRK1A, RNF169, TP53BP1, and UIMC1 (SP-RNF169, gomodel:617b481400003575). At a DNA double-strand break (DSB) site, DYRK1A (Q13627) positively regulates RNF169 (Q8NCN4) through its protein serine kinase activity (GO:0106310). RNF169, with its ubiquitin-modified histone reader activity (GO:0061649), negatively regulates both TP53BP1 (Q12888) and UIMC1 (Q96RL1) at the DSB site (GO:0035861). This regulation determines DNA repair pathway choice: RNF169 promotes homologous recombination (GO:0000724), while TP53BP1 and UIMC1 promote non-homologous end joining (GO:0006303).
Feedback from AI on figure:
{"feedback":"This diagram clearly illustrates the DNA damage response pathway described in the GO-CAM model. The color coding effectively distinguishes between different types of proteins (kinases, HR factors, and NHEJ factors), while the differently styled arrows distinguish between regulatory relationships and pathway associations. The diagram shows the nuclear context of repair pathway choice at double-strand breaks, with DYRK1A's positive regulation of RNF169 and RNF169's negative regulation of both TP53BP1 and UIMC1 clearly depicted. The molecular functions are properly labeled, and the overall presentation is clean and professional, suitable for a scientific journal.","necessary_changes":null,"optional_changes":null}