Figure: ERBB2-EGFR signaling pathway 1 (Mouse)¶
This figure illustrates the ERBB2-EGFR signaling pathway in mouse (Mus musculus). The pathway begins with ADAM17 (metalloendopeptidase) cleaving the HB-EGF precursor on the plasma membrane (Step 1). The mature HB-EGF is then released into the extracellular space (Step 2), where it functions as a receptor ligand. HB-EGF binds to EGFR on the plasma membrane (Step 3), activating it. The activated EGFR then interacts with ERBB2 (Step 4), which exhibits protein tyrosine kinase activity, thus initiating the ERBB2-EGFR signaling pathway. The color-coding distinguishes between different molecular components: ADAM17 (red), HB-EGF (green), EGFR (blue), and ERBB2 (pink).
Feedback from AI on figure:
{"feedback":"This final diagram effectively captures the ERBB2-EGFR signaling pathway with excellent clarity and scientific accuracy. All components from the GO-CAM model are clearly represented, including ADAM17 (metalloendopeptidase), HB-EGF (both precursor and mature forms), EGFR, and ERBB2. The sequential steps of the pathway are well-illustrated with numbered steps and directional arrows showing the flow, making it easy to follow the biological process. The increased font sizes throughout improve readability substantially. The inclusion of both a color-coded legend and step-by-step explanation enhances understanding for readers. The cellular compartments (extracellular space and plasma membrane) are distinctly marked, providing important spatial context for the interactions. The diagram successfully balances scientific detail with visual clarity in a style suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}