Figure: Silencing of fetal hemoglobin by ZNF410 (Human)¶
This pathway diagram illustrates the molecular mechanism of fetal hemoglobin silencing by ZNF410 in human cells.
Key components: • ZNF410: A DNA-binding transcription factor (GO:0003700) in erythroid lineage cells • CHD4: A transcription corepressor (GO:0003714) activated by ZNF410 • HBG1/HBG2: Genes encoding fetal hemoglobin subunits that are repressed by CHD4 • Erythrocyte: Cell type where fetal hemoglobin functions as an oxygen carrier
The pathway shows: 1. ZNF410 activates CHD4 through positive regulation of transcription (GO:0045944) 2. CHD4 represses both HBG1 and HBG2 gene expression (GO:0010629) 3. Reduced expression of fetal hemoglobin components in erythrocytes 4. Impact on oxygen carrier activity (GO:0005344) and oxygen transport (GO:0015671)
The diagram uses color-coded arrows to distinguish activation (green) from repression (red) pathways, with dashed blue lines indicating gene expression processes.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the silencing mechanism of fetal hemoglobin by ZNF410 in human cells. The pathway is clearly depicted with visually distinct components and well-labeled interactions. The color-coded arrows enhance understanding of the regulatory relationships, with green indicating activation and red showing repression. The cellular context is well-represented, showing both the erythroid lineage cell and the erythrocyte, with appropriate subcellular localization of proteins. Text is appropriately sized and positioned, making all elements readable. The legend provides comprehensive information about the pathway components and interaction types. The diagram successfully balances scientific accuracy with visual clarity, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}