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Figure: Epidermal growth factor receptor signaling pathway 2 (Mouse)

id: gomodel:6197061700001622

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Figure legend: Epidermal Growth Factor Receptor Signaling Pathway in Mouse (Mus musculus)

This diagram illustrates the EGFR signaling pathway based on GO-CAM model 6197061700001622. The pathway shows how TGFα (Tgfa) is processed and activates EGFR (Egfr):

  1. Metallodipeptidases ADAM17 and MEP1A (shown in yellow) are anchored in the plasma membrane where they cleave TGFα precursor proteins (shown as red polygons).

  2. This cleavage releases mature TGFα (red circle) into the extracellular space, where it functions as a receptor ligand.

  3. Mature TGFα binds to and activates EGFR (green rectangle) on the plasma membrane, which has transmembrane receptor protein tyrosine kinase activity.

  4. EGFR activation initiates the epidermal growth factor receptor signaling pathway (GO:0007173), represented by the dashed arrow.

The diagram represents signaling events defined in the GO-CAM model, including the signaling receptor ligand precursor processing (GO:0140448) activity of ADAM17 and MEP1A, and the receptor ligand activity of TGFα in the extracellular space (GO:0005615).

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the EGFR signaling pathway in mouse as specified in the GO-CAM model. The key molecular components (ADAM17, MEP1A, TGFα precursor, mature TGFα, and EGFR) are clearly represented with appropriate visual elements, and their spatial organization accurately depicts their cellular localization (plasma membrane, extracellular space). The process flow is well-illustrated with directional arrows and descriptive labels that explain the relationships between components (cleaves, releases, activates). The diagram shows how ADAM17 and MEP1A cleave TGFα precursor, releasing mature TGFα into the extracellular space, which then activates EGFR to initiate signaling. The visual style is appropriate for a scientific journal, with clean lines, clear labeling, and a professional color scheme.","necessary_changes":null,"optional_changes":null}