Figure: Epidermal growth factor receptor signaling pathway 3 (Mouse)¶
This figure illustrates the epidermal growth factor receptor signaling pathway in mouse. The diagram shows how Adam17 (metallopeptidase) cleaves the membrane-bound Areg (amphiregulin) precursor, releasing active Areg into the extracellular space. The active Areg ligand then binds to and activates the Egfr (epidermal growth factor receptor) on the cell surface, leading to receptor phosphorylation and downstream signaling. Key molecular functions are annotated with their corresponding Gene Ontology terms.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the epidermal growth factor receptor signaling pathway in mouse, showing the relationship between Adam17, Areg, and Egfr across cellular compartments. The use of distinct colors and shapes helps differentiate components, while the comprehensive legend clarifies the meaning of each element. Font sizes have been increased to improve readability, and the addition of descriptive text about causal relationships enhances understanding of the pathway's molecular mechanisms.","necessary_changes":null,"optional_changes":"Future iterations could include downstream signaling events or cross-talk with other pathways if relevant to the specific biological context being illustrated."}