Figure: ERBB2-ERBB4 signaling pathway 2 (Mouse)ΒΆ
The diagram illustrates the ERBB2-ERBB4 signaling pathway in mice, depicting three cellular compartments: extracellular space, plasma membrane, and cytoplasm.
Key components in the pathway include: 1. ADAM17 (metallopeptidase) in the plasma membrane that cleaves the Ereg precursor 2. Ereg (epiregulin) functioning as a receptor ligand in the extracellular space 3. ERBB4 (transmembrane receptor tyrosine kinase) in the plasma membrane 4. ERBB2 (tyrosine kinase) in the plasma membrane 5. ERBB2-ERBB4 signaling complex formation in the cytoplasm
The pathway shows how ADAM17 processes the Ereg precursor, liberating the mature Ereg ligand. The Ereg ligand then binds to ERBB4 receptor at the plasma membrane, leading to ERBB4 activation of ERBB2, and subsequent formation of the ERBB2-ERBB4 signaling complex.
Components or processes not explicitly mentioned in the source data but implied by biological context are marked with "(not in source)".
Feedback from AI on figure:
{"feedback":"The drawing clearly illustrates the ERBB2-ERBB4 signaling pathway in mice. The spatial organization into distinct cellular compartments (extracellular space, plasma membrane, and cytoplasm) effectively shows where each process occurs. All key proteins (ADAM17, Ereg, ERBB4, and ERBB2) are well-represented with appropriate shapes and colors that help distinguish their functional roles. The arrows showing the relationships between components accurately capture the signaling flow from Ereg precursor processing to receptor activation and complex formation. The added legend enhances understanding of the symbols used and clearly identifies elements not explicitly mentioned in the source data.","necessary_changes":null,"optional_changes":null}