Figure: Fatty acid transport by CD36 via LYN-mediated endocytosis (Human)¶
This figure illustrates the fatty acid transport mechanism mediated by CD36 and LYN-mediated endocytosis in human cells as described in the GO-CAM model.
The pathway depicts: 1) Fatty acid binding to CD36 receptor on the plasma membrane 2) CD36 activation of LYN kinase 3) LYN activation of ZDHHC5 palmitoyltransferase 4) ZDHHC5 regulation of LYPLA1 palmitoyl hydrolase activity 5) Subsequent fatty acid transport into the cell
Key proteins: - CD36 (P16671): Functions as a cargo receptor for fatty acids - LYN (P07948): Protein tyrosine kinase that mediates signaling - ZDHHC5 (Q9C0B5): Palmitoyltransferase involved in protein modification - LYPLA1 (O75608): Palmitoyl hydrolase that removes palmitoyl groups
The endocytic vesicle (shown in purple dashed outline) is implied but not explicitly stated in the source GO-CAM model.
Feedback from AI on figure:
{"feedback":"The diagram effectively visualizes the fatty acid transport mechanism through CD36 and LYN-mediated endocytosis. The illustration clearly separates cellular compartments and shows the sequential activation of proteins involved in the pathway. The use of color-coding for different proteins and processes enhances clarity, and the comprehensive legend helps interpret the molecular interactions. The spacing between labels and components has been improved to reduce crowding, making the figure more readable. The addition of the endocytosis visualization (marked as implied) helps complete the biological story while being transparent about information that was inferred beyond the original GO-CAM model.","necessary_changes":null,"optional_changes":null}