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Figure: NLRP6 inflammasome (Human)

id: gomodel:61b2b68300000000

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The diagram illustrates the NLRP6 inflammasome pathway in human cells:

  1. NLRP6 functions as a pattern recognition receptor in the cytosol that can detect viral double-stranded RNA (dsRNA) and bacterial lipoteichoic acid (LTA).

  2. Upon recognition of these pathogen-associated molecular patterns, NLRP6 undergoes molecular condensation and assembles into an inflammasome complex.

  3. The NLRP6 inflammasome activates Caspase-1 (CASP1), a cysteine protease that:

  4. Cleaves pro-IL-1β to produce active IL-1β
  5. Cleaves pro-IL-18 to produce active IL-18

  6. Cleaves Gasdermin D (GSDMD)

  7. Activated GSDMD forms pores in the plasma membrane, facilitating:

  8. Release of mature IL-1β and IL-18 cytokines to the extracellular space
  9. Induction of pyroptotic cell death

This pathway plays a crucial role in innate immune responses against viral and bacterial infections by triggering inflammation and specialized cell death.

Feedback from AI on figure:

{"feedback":"This diagram effectively captures the NLRP6 inflammasome pathway as described in the GO-CAM model. The illustration maintains scientific accuracy while using artistic techniques appropriate for a high-impact journal figure. The diagram successfully shows the progression from pathogen recognition to inflammasome assembly, caspase activation, and the downstream effects including cytokine processing and pyroptosis.","necessary_changes":null,"optional_changes":"The diagram could potentially benefit from more detailed molecular representations of the inflammasome complex assembly structure, though this would be a stylistic choice rather than a necessary improvement."}