Figure: ERBB2-ERBB4 signaling pathway 3 (Mouse)¶
The diagram illustrates the ERBB2-ERBB4 signaling pathway in mouse cells. At the plasma membrane, three metalloproteases (ADAM10, ADAM17, and BACE1, shown in turquoise) cleave the NRG1 precursor (yellow) in the cytoplasm, releasing mature NRG1 into the extracellular space. Mature NRG1 binds to the ERBB4 receptor (purple) at the plasma membrane, which then dimerizes with ERBB2. This activates the receptor complex (red), initiating the ERBB2-ERBB4 signaling pathway through protein tyrosine kinase activity. Each component is color-coded for clarity, with arrows indicating the direction of processes. The diagram faithfully represents the GO-CAM model, showing how receptor ligand precursor processing leads to downstream ERBB2-ERBB4 signaling.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the ERBB2-ERBB4 signaling pathway in mouse cells, with clear stages from NRG1 processing to signaling activation. The improved font sizes greatly enhance readability, especially in the legend and process labels, which are crucial for understanding the diagram. The color coding is consistent and aids in distinguishing different components of the pathway, such as metallopeptidases, receptor ligands, receptors, and activated complexes. The labels and arrows are clearly placed, directing the viewer's eye logically through the pathway steps. The addition of arrow legends helps clarify the meaning of different arrow styles, and the reference note provides appropriate attribution to the source GO-CAM model. Overall, the diagram is well-structured, informative, and suitable for publication in a scientific journal.","necessary_changes":null,"optional_changes":null}