Figure: ERBB2-ERBB3 receptor signaling pathway involved in myelination 1 (Mouse)¶
This diagram illustrates the ERBB2-ERBB3 receptor signaling pathway involved in myelination in mouse cells. The pathway is organized vertically through three cellular compartments: the extracellular space (top), plasma membrane (middle), and cytosol (bottom).
The signaling cascade begins with Neuregulin-1 (Nrg1) in the extracellular space, which activates ERBB2-ERBB3 receptor heterodimers in the plasma membrane. This activation triggers recruitment of adaptor proteins Grb2 and Sos1 in the cell cortex region. Sos1 then activates Hras at the plasma membrane, which initiates the MAPK cascade in the cytosol.
The MAPK cascade proceeds through sequential activation of kinases: Raf1, Map2k1/2 (MEK1/2), and Mapk1/3 (ERK1/3). This signaling pathway ultimately regulates myelination, the process by which Schwann cells insulate nerve axons in the peripheral nervous system.
Color coding in the diagram distinguishes between ligands (orange), receptors (blue), adaptor proteins (green), and kinases (purple), with arrows indicating the direction of signal transduction and activation events.
Feedback from AI on figure:
{"feedback":"The pathway diagram effectively communicates the ERBB2-ERBB3 receptor signaling pathway involved in myelination. The clearly defined cellular compartments (extracellular space, plasma membrane, and cytosol) establish the spatial context for the signaling events. The sequential flow from Nrg1 binding to the final outcome of myelination is logically organized and easy to follow. The color-coding system, detailed in the legend, helps distinguish between different protein types (ligands, receptors, adaptor proteins, and kinases), making the diagram more accessible to readers. The labeled activation arrows clearly show the relationships between pathway components. The addition of GO terms for cellular compartments provides valuable reference information for researchers, while the pathway description at the bottom offers context about the biological significance of this signaling cascade.","necessary_changes":null,"optional_changes":null}