Figure: Epidermal growth factor receptor signaling pathway 10 (Mouse)¶
This figure illustrates the Epidermal Growth Factor Receptor (EGFR) signaling pathway in mouse (GO:0007173). The pathway begins with TGFα ligand (MGI:98724) in the extracellular space binding to EGFR (MGI:95294) at the plasma membrane. Upon binding, EGFR activates its intrinsic tyrosine kinase domain (GO:0004713), which recruits the adaptor protein Grb2 (MGI:95805) at the cell cortex. Grb2 then recruits the signaling adaptor Gab1 (MGI:108088), also at the cell cortex. Finally, Gab1 activates the non-membrane spanning protein tyrosine phosphatase Ptpn11 (MGI:99511) in the cytosol, completing this specific signaling cascade. Each component is represented with a distinct shape and color, with ligands as blue circles, receptors as red rectangles, adaptors as orange and green shapes, and enzymes as purple ellipses. The cellular compartments (extracellular space, plasma membrane, cell cortex, and cytosol) are color-coded to indicate the subcellular localization of each protein in the pathway.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the Epidermal Growth Factor Receptor signaling pathway in mice as described in the GO-CAM model. It clearly depicts the molecular interactions and subcellular localizations of all components, showing how the signal progresses from the extracellular space through the plasma membrane into the cell cortex and cytosol. The color-coding and distinct shapes help distinguish between different protein types (ligands, receptors, adaptors, and enzymes), while the directional arrows clearly indicate the flow of signaling. The inclusion of GO term identifiers provides valuable reference information, and the overall layout adheres to publication standards for scientific journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}