Figure: Activation of ALK and LTK by ALKAL1 and ALKAL2 cytokines (Human)¶
This figure illustrates the activation pathway of ALK (Anaplastic Lymphoma Kinase, Q9UM73) and LTK (Leukocyte Tyrosine Kinase, P29376) by ALKAL1 (ALK And LTK Ligand 1, Q6UXT8) and ALKAL2 (ALK And LTK Ligand 2, Q6UX46) cytokines in human cells.
The cytokines ALKAL1 and ALKAL2 are shown in the extracellular space (GO:0005615) exhibiting cytokine activity (GO:0005125). They activate the receptor tyrosine kinases ALK and LTK located in the plasma membrane (GO:0005886), which possess transmembrane receptor protein tyrosine kinase activity (GO:0004714). ALK also demonstrates heparin binding capability (GO:0008201), which facilitates its interactions.
These molecular interactions collectively contribute to the cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169). The red arrows indicate activation relationships between the cytokines and receptors, while the dashed line represents the binding interaction between ALK and heparin.
Feedback from AI on figure:
{"feedback":"The diagram clearly depicts the activation of ALK and LTK receptor tyrosine kinases by ALKAL1 and ALKAL2 cytokines in human cells. The illustration effectively organizes cellular compartments (extracellular space, plasma membrane, cytoplasm) and shows the key interactions between components.\n\nAll gene products are properly labeled with both gene names and UniProt identifiers (Q6UXT8, Q6UX46, Q9UM73, P29376), and GO terms are accurately indicated (GO:0005615, GO:0005886, GO:0005125, GO:0004714, GO:0008201, GO:0007169). The activation relationships are clearly shown with directional arrows, and the heparin binding interaction is appropriately distinguished with a dashed line.\n\nThe color coding, consistent styling, and informative legend enhance the diagram's readability, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}