Figure: IL23 signaling pathway (Human)ΒΆ
This diagram illustrates the IL-23 signaling pathway in humans, showing the molecular interactions from the extracellular ligand binding to gene regulation in the nucleus. The IL-23 cytokine complex (composed of IL23A and IL12B subunits) binds to its receptor complex on the cell surface, consisting of IL23R (receptor) and IL12RB1 (coreceptor). This binding activates the associated JAK2 and TYK2 tyrosine kinases on the cytoplasmic side of the plasma membrane, which then phosphorylate and activate STAT3 and STAT4 transcription factors. The activated STATs translocate to the nucleus where they regulate gene expression. Each protein is represented with its UniProt ID, and the molecular functions and cellular locations are annotated with their respective GO terms. The entire pathway is part of the interleukin-23-mediated signaling pathway (GO:0038155).
Feedback from AI on figure:
{"feedback":"This diagram effectively captures the IL-23 signaling pathway in a publication-ready format suitable for journals like Cell or Nature. The pathway components are clearly represented with proper protein identification (names and UniProt IDs), relevant GO terms for molecular functions and cellular locations, and correct biological interactions. The diagram follows a logical flow from extracellular cytokine binding through intracellular signal transduction to nuclear activities. The improved font sizes enhance readability, and the consistent use of curved arrows provides a professional aesthetic. The color-coded legend helps readers quickly understand the different protein types involved in the pathway. All components from the GO-CAM model are faithfully represented, including the IL-23 complex (IL23A+IL12B), receptor components (IL23R, IL12RB1), kinases (JAK2, TYK2), and transcription factors (STAT3, STAT4), along with their respective cellular localizations and molecular functions.","necessary_changes":null,"optional_changes":null}