Figure: Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human)¶
This figure illustrates the regulation of gluconeogenesis in human cells, depicting the intricate interplay between key regulators SIRT6, SIRT1, KAT2A (GCN5), FOXO1, and PPARGC1A (PGC-1α). All regulatory interactions occur within the nucleus. SIRT6 inhibits KAT2A acetyltransferase activity, which in turn negatively regulates PPARGC1A. SIRT6 also inhibits FOXO1 and promotes protein export from the nucleus. SIRT1 positively regulates both FOXO1 and PPARGC1A while also maintaining nuclear location. FOXO1, as a transcription factor, and PPARGC1A, as a transcriptional coactivator, both activate gluconeogenesis. Green solid arrows indicate activation, red dashed arrows represent inhibition, and blue arrows denote cellular localization effects.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the regulation of gluconeogenesis by SIRT6, FOXO1, SIRT1, and KAT2A/GCN5 in human cells. The layout clearly shows all protein interactions occurring within the nucleus with distinctive visual elements to represent different types of proteins and regulatory relationships. The use of color-coding and different line styles (solid for activation, dashed for inhibition) makes the regulatory relationships immediately clear. The proteins are well-spaced and appropriately sized, with legible labels. The legend provides clear information about the different components in the diagram. All the key elements from the GO-CAM model are faithfully represented, including SIRT6's role in nuclear export, SIRT1's maintenance of nuclear location, and the respective positive and negative regulatory relationships between the proteins that ultimately affect gluconeogenesis.","necessary_changes":null,"optional_changes":null}