Figure: SIRT6 inactivation by lncPRESS1 RNA (Human)¶
This figure illustrates the molecular pathway by which lncPRESS1 RNA inactivates SIRT6 protein in human cells, leading to positive regulation of stem cell differentiation. The pathway is organized into four steps:
Step 1: RNA-Protein Interaction - lncPRESS1 RNA (URS0000BC450A_9606) binds to SIRT6 protein (Q8N6T7) through RNA-protein binding activity (GO:0106222, lncRNA binding).
Step 2: SIRT6 Inactivation - The binding of lncPRESS1 leads to functional inactivation of SIRT6.
Step 3: Downstream Effects - Inactive SIRT6 shows inhibition of both chromatin binding activity (GO:0003682) and histone deacetylase activity (GO:0017136).
Step 4: Cellular Process Outcome - The inhibition of SIRT6 functions ultimately results in positive regulation of stem cell differentiation (GO:2000738) and negative regulation of protein localization to chromatin (GO:0120186).
All interactions occur within the nucleus, specifically at chromatin (GO:0000785). The diagram is based on the GO-CAM model "SIRT6 inactivation by lncPRESS1 RNA (Human)" (gomodel:6205c24300000050).
Feedback from AI on figure:
{"feedback":"This molecular pathway diagram effectively illustrates the interaction between lncPRESS1 RNA and SIRT6, showing how their binding relationship affects chromatin function and stem cell differentiation. The step-by-step organization makes the progression of the pathway clear and intuitive, while color coding and directional arrows help distinguish between activation and inhibition processes. The improved text size enhances readability, and the added explanatory annotations for each step provide necessary context for understanding the biological significance of each interaction. The comprehensive legend explains all symbols and elements used in the diagram, making it accessible even to readers less familiar with the specific pathway.","necessary_changes":null,"optional_changes":null}