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Figure: Microtubule polyglutamylation regulation (Human)

id: gomodel:6205c24300000330

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The diagram illustrates the microtubule polyglutamylation regulation pathway in humans.

Key Components: - Microtubule (blue bar): The structural component where polyglutamylation occurs - Centriolar Satellite (green circle): A subcellular structure involved in regulating the pathway - Proteins are color-coded by function: * Ligase (pink): TTLL1, responsible for adding glutamate residues * Target Protein (light blue): MAP4, which is stabilized by polyglutamylation * Adaptor Proteins (light green): TPGS1, TPGS2, LRRC49, which facilitate molecular interactions * Kinases (beige): CDK1, MARK4, which negatively regulate the pathway * Scaffold Proteins: PCM1 and CSTPP1 at the centriolar satellite

Interactions: - Green arrows indicate positive regulation - Red arrows indicate negative regulation - Dashed lines indicate regulatory pathways from the centriolar satellite

The pathway demonstrates how microtubule polyglutamylation is regulated through complex interactions between proteins at the microtubule and centriolar satellite, ultimately affecting microtubule stability and organization during cellular processes.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the microtubule polyglutamylation regulation pathway in a clear, scientifically accurate manner suitable for publication in journals like Cell or Nature. The color-coding of proteins by function helps distinguish their roles, and the directional arrows clearly represent the regulatory relationships between components. The inclusion of cellular context with the microtubule and centriolar satellite provides spatial organization that enhances understanding of the pathway.","necessary_changes":null,"optional_changes":null}