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Figure: IL2 signaling pathway (Human)

id: gomodel:6205c24300001663

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IL-2 Signaling Pathway (Human)

The diagram illustrates the interleukin-2 (IL-2) signaling pathway in human cells, showing the cascade from IL-2 cytokine binding to gene regulation.

Key components: - IL-2 (P60568): Cytokine released into extracellular space - IL-2RA (P01589): Alpha subunit of IL-2 receptor - IL-2RB (P14784): Beta subunit of IL-2 receptor - IL-2RG (P31785): Gamma subunit of IL-2 receptor (common gamma chain) - JAK1 (P23458): Janus kinase 1 - JAK3 (P52333): Janus kinase 3 - STAT5A (P42229): Signal transducer and activator of transcription 5A - STAT3 (P40763): Signal transducer and activator of transcription 3

Signaling steps: 1. IL-2 binding to IL-2 receptor complex on plasma membrane 2. Receptor activation leads to JAK recruitment 3. JAK phosphorylation of STATs 4. STAT translocation to nucleus 5. Gene regulation by STAT transcription factors

Feedback from AI on figure:

{"feedback":"The IL-2 signaling pathway diagram effectively represents the biological process described in the GO-CAM model. The illustration is clear, uses appropriate scientific styling suitable for journals like Cell or Nature, and accurately depicts the relationships between components. The use of different shapes and colors for various molecular elements (cytokines, receptors, kinases, and transcription factors) enhances readability and understanding.","necessary_changes":null,"optional_changes":null}