Figure: Fructose catabolic process (Mouse)¶
This diagram illustrates the fructose catabolic process (GO:0006001) in mouse cytosol (GO:0005829), based on GO-CAM model gomodel:622aace900000443.
The pathway begins with fructose being phosphorylated by ketohexokinase (Khk/MGI:MGI:1096353) to form fructose-1-phosphate. This is then cleaved by fructose-1-phosphate aldolase (Aldob/MGI:MGI:87995) into two products: glyceraldehyde and dihydroxyacetone phosphate (DHAP).
DHAP enters glycolysis (shown as an implicit step), while glyceraldehyde is oxidized to glycerate by two aldehyde dehydrogenases (Aldh1a1/MGI:MGI:1353450 and Aldh1a7/MGI:MGI:1347050), which use NAD+ as a cofactor. Finally, glycerate kinase (Glyctk/MGI:MGI:2444085) phosphorylates glycerate to form glycerate-3-phosphate, which can enter glycolysis at the 2-phosphoglycerate stage.
Different colored arrows distinguish reaction types: green for phosphorylation, purple for aldolase cleavage, red for dehydrogenation, blue for kinase reactions, and gray dashed lines for implicit connections to glycolysis.
Feedback from AI on figure:
{"feedback":"The drawing effectively illustrates the fructose catabolic process in mouse cytosol with clear organization and visual hierarchy. The colored arrows successfully differentiate between reaction types (phosphorylation, aldolase cleavage, dehydrogenation, and kinase reactions), making the pathway flow intuitive to follow. The detailed labels for each enzyme, including their function, along with substrate/product information and cofactors, provide comprehensive information about each reaction step. The inclusion of implicit connections to glycolysis with appropriate labeling helps contextualize the pathway within broader metabolism. The legend is detailed and informative, enhancing understanding of the diagram's elements.","necessary_changes":null,"optional_changes":null}