Figure: Galactose catabolic process via UDP-galactose¶
The diagram illustrates the galactose catabolic process via UDP-galactose (GO:0033499) in mouse. The pathway begins with beta-D-galactose, which is converted to alpha-D-galactose by Galm (aldose 1-epimerase). Alpha-D-galactose is phosphorylated to galactose-1-phosphate by Galk1 (galactokinase). Galt (UDP-glucose:hexose-1-phosphate uridylyltransferase) then exchanges the phosphate group with UDP-glucose to produce UDP-galactose and glucose-1-phosphate. UDP-galactose is converted to UDP-glucose by Gale (UDP-glucose 4-epimerase). The glucose-1-phosphate can be further metabolized to glucose-6-phosphate via Pgm1/Pgm2 (phosphoglucomutase) activity, enabling entry into glycolysis. The diagram shows enzymes (orange boxes), metabolites (blue hexagons), reactions (solid arrows), and implicit pathways (dashed lines).
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively visualizes the galactose catabolic process via UDP-galactose in mice, following journal publication standards. The use of distinct shapes, consistent color coding, and clear labeling makes the biochemical transformations easy to follow. The hexagon shapes for metabolites and rectangular shapes for enzymes create a visually intuitive representation. The addition of the role explanation for Pgm1/Pgm2 provides helpful context, and the comprehensive legend enhances understanding of the diagram elements. The pathway is accurately depicted with all key enzymes (Galm, Galk1, Galt, Gale, Pgm1/Pgm2) and metabolites (β-D-galactose, α-D-galactose, galactose-1-P, UDP-galactose, UDP-glucose, glucose-1-P, glucose-6-P) clearly represented.","necessary_changes":null,"optional_changes":null}