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Figure: Pentose-phosphate shunt 1 (Mouse)

id: gomodel:622aace900000962

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The figure illustrates the pentose-phosphate shunt pathway in mouse cells, comprising two connected branches:

  1. Oxidative Branch (left, blue): Involves the sequential action of glucose-6-phosphate dehydrogenase (G6pd2/G6pdx), 6-phosphogluconolactonase (Pgls), and 6-phosphogluconate dehydrogenase (Pgd). This branch generates NADPH as a key product.

  2. Non-oxidative Branch (right, red): Includes ribose-5-phosphate isomerase (Rpia), ribulose-5-phosphate epimerase (Rpe), transketolase (Tkt), and transaldolase (Taldo1). This branch connects back to the beginning of the pathway, creating a metabolic cycle.

All reactions occur in the cytosol (GO:0005829). The pathway recycles fructose-6-phosphate (CHEBI:57634) and generates NADPH (CHEBI:57783), important for cellular redox balance and biosynthetic processes.

Gene products are shown with their corresponding GO molecular function terms. Arrows indicate the direction of metabolic flow through the pathway.

Feedback from AI on figure:

{"feedback":"This diagram effectively represents the pentose-phosphate shunt pathway in mouse cells with excellent scientific and artistic quality. The illustration clearly distinguishes between the oxidative branch (in blue) and non-oxidative branch (in red), with appropriate enzyme labeling including both gene names and GO terms. The pathway flow is easy to follow with directional arrows showing the cyclical nature of the process. The production of NADPH is highlighted appropriately, and the inclusion of intermediate metabolites enhances understanding of the pathway's progression. The diagram includes a comprehensive legend explaining color coding and symbols, making it accessible to both expert and non-expert audiences. The cellular context (cytosol) is clearly indicated, and the overall layout adheres to publication standards expected in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}