Skip to content

Figure: Pentose-phosphate shunt 2 (Mouse)

id: gomodel:622aace900001389

img

The diagram illustrates the pentose-phosphate shunt in mouse cytosol (GO:0005829), highlighting the sequential activities of three key enzymes:

  1. Rbks (ribokinase, GO:0004747) converts D-ribofuranose (CHEBI:47013) to D-ribose 5-phosphate (implied intermediate).

  2. Tkt (transketolase, GO:0004802) processes D-ribose 5-phosphate and produces two outputs: β-D-fructofuranose 6-phosphate(2-) (CHEBI:57634) and D-glyceraldehyde 3-phosphate(2-) (CHEBI:59776).

  3. Taldo1 (transaldolase, GO:0004801) acts downstream of Tkt activity.

All three enzyme activities are part of the pentose-phosphate shunt biological process (GO:0006098). The diagram shows two regulatory relationships: Rbks activity positively regulates Tkt activity, and Tkt activity positively regulates Taldo1 activity, representing the sequential flow through this metabolic pathway.

Note: D-ribose 5-phosphate is shown as an implied intermediate based on ribokinase activity, as it is not explicitly listed in the source GO-CAM model but is necessary to represent the pathway accurately.

Feedback from AI on figure:

{"feedback":"The diagram effectively illustrates the pentose-phosphate shunt pathway in mouse with clarity and scientific accuracy. The sequential arrangement of enzyme activities (Rbks → Tkt → Taldo1) is clearly depicted with appropriate directional arrows. The diagram successfully balances scientific detail with visual clarity by including gene product identifiers, GO terms, and CHEBI identifiers while maintaining an uncluttered appearance. The cytosolic localization is clearly indicated, and the implied D-ribose 5-phosphate intermediate is appropriately labeled to distinguish it from explicitly stated components. The colored coding system (red for enzymes, blue for metabolites) enhances readability, and the dotted lines connecting enzymes to the pentose-phosphate shunt biological process effectively show their participation in this pathway. The addition of regulatory relationships between enzyme activities accurately represents the causal associations in the GO-CAM model.","necessary_changes":null,"optional_changes":null}