Figure: Glycogen biosynthetic process (Mouse)¶
The diagram depicts the glycogen biosynthesis pathway in mouse (GO:0005978), showing key enzymes and their interactions within the cytosol (GO:0005829).
The pathway begins with Pgm1/Pgm2 (phosphoglucomutase) converting glucose-6-phosphate to glucose-1-phosphate. Ugp2 (UTP:glucose-1-phosphate uridylyltransferase) then converts glucose-1-phosphate to UDP-glucose, which serves as the glucose donor for subsequent reactions.
Gyg1 (glycogenin) self-glucosylates to form the initial glycogen primer. Subsequently, Gys1/Gys2 (glycogen synthase) elongates this primer by adding glucosyl units via α-1,4-linkages. Finally, Gbe1 (branching enzyme) creates branches by forming α-1,6-linkages, resulting in mature glycogen.
The pathway is regulated by several proteins: - Ppp1r3c acts as a molecular adaptor to activate glycogen synthase - Epm2a (laforin) controls glycogen dephosphorylation and regulates glycogen quality - Nhlrc1 (malin) functions as a ubiquitin transferase involved in protein degradation
Direct effects are shown with solid arrows, while regulatory relationships are indicated with dashed arrows. Items marked with an asterisk (*) represent implicit elements not explicitly mentioned in the GO-CAM but included for pathway clarity.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the glycogen biosynthesis pathway in mice, with clear representation of all key enzymes from the GO-CAM model. The sequential arrangement of proteins shows the logical flow of the process from glucose phosphate conversion through to mature glycogen formation. \n\nThe use of color-coded elements (blue protein boxes, light green process annotations) creates visual organization that helps distinguish different components of the pathway. The addition of concise process descriptions for each step greatly enhances comprehension, explaining the specific biochemical transformations that occur.\n\nRegulatory relationships are well-depicted using dashed lines, clearly distinguishing them from direct enzymatic activities. The implicit glucose-6-phosphate starting material is appropriately marked as not being explicitly in the source GO-CAM.\n\nThe diagram follows professional scientific journal figure standards, with a clean layout, proper spacing between elements, and readable fonts. The legend efficiently summarizes the pathway components and their interactions.","necessary_changes":null,"optional_changes":null}