Figure: IL4-mediated signaling pathway (human)¶
This figure illustrates the IL4-mediated signaling pathway in humans, showing the sequential activation steps from IL4 binding to transcription factor translocation. The pathway begins with IL4 cytokine binding to IL4R at the plasma membrane, which recruits the IL2RG coreceptor. This receptor complex activates JAK1 and JAK3 kinases, which then phosphorylate downstream transcription factors STAT6 and STAT5A. Upon activation, these transcription factors translocate to the nucleus to regulate gene expression. Numbered circles indicate the sequence of signaling events.
Feedback from AI on figure:
{"feedback":"This diagram effectively represents the IL4-mediated signaling pathway as described in the GO-CAM, with clear visualization of the key components and their relationships. The pathway flow is logically organized from extracellular IL4 binding to nuclear translocation of transcription factors. The use of distinct shapes and colors for different molecular types (cytokines, receptors, kinases, and transcription factors) enhances clarity, while numbered markers effectively show the sequential nature of the signaling events. Text labels are appropriately sized and clearly visible throughout the diagram.","necessary_changes":null,"optional_changes":null}