Figure: IL3-mediated signaling pathway (Human)¶
This figure illustrates the IL3-mediated signaling pathway in human cells. The pathway begins with IL3 cytokine (P08700) in the extracellular space binding to its receptor IL3RA (P26951) on the plasma membrane. IL3RA forms a complex with the coreceptor CSF2RB (P32927). This receptor complex activates JAK2 kinase (O60674), which is associated with the plasma membrane. Activated JAK2 phosphorylates the transcription factor STAT5A (P42229), which then translocates to the nucleus where it binds DNA to regulate gene expression. Each component is represented with distinct shapes and colors: cytokines (circles), receptors and coreceptors (rounded rectangles), kinases (rectangles), and transcription factors (diamonds). GO terms are included for molecular functions and cellular locations. The figure is based on the IL3-mediated signaling pathway (GO:0038156) as defined in the GO-CAM model.
Feedback from AI on figure:
{"feedback":"This diagram effectively illustrates the IL3-mediated signaling pathway in human cells with clarity and scientific accuracy. The cellular compartments are clearly delineated with appropriate labels, and the pathway components are visually distinct with consistent use of shapes and colors. The directional flow of the signaling cascade is well represented through clear arrows and additional text labels explaining each step of the process. The inclusion of GO terms enhances the scientific value of the illustration, and the legend provides comprehensive information about each component. The note about implied details (STAT5A phosphorylation and translocation) appropriately indicates where artistic license was taken to complete the pathway visualization.","necessary_changes":null,"optional_changes":null}