Figure: IL5-mediated signaling pathway (Human)¶
This figure illustrates the IL5-mediated signaling pathway in human eosinophils. The pathway begins with IL5 (P05113) in the extracellular space binding to its receptor complex consisting of IL5RA (Q01344) and CSF2RB (P32927) on the eosinophil plasma membrane. This receptor engagement activates two tyrosine kinases: JAK2 (O60674) and LYN (P07948), which phosphorylate the transcription factor STAT5A (P42229). Upon phosphorylation, STAT5A translocates to the nucleus where it binds to DNA to regulate gene expression. The pathway ultimately leads to eosinophil differentiation and activation.
Feedback from AI on figure:
{"feedback":"The drawing effectively captures the IL5-mediated signaling pathway with excellent clarity and scientific accuracy. The illustration follows the journal-quality standards expected in publications like Cell or Nature with clear cellular compartmentalization, professional color-coding, and accurate representation of the signaling cascade. The improved text size and readability throughout the diagram, along with clear directionality of signal flow using appropriate arrows makes the pathway easy to follow. The distinct visual representation of translocation events using green dashed arrows effectively distinguishes this process from other interactions.","necessary_changes":null,"optional_changes":null}