Figure: Renin-angiotensin pathway (Human)¶
This diagram illustrates the human renin-angiotensin pathway (GO-CAM:6246724f00000549), a critical system for blood pressure regulation and fluid homeostasis.
Key components: - Renin (P00797-1): An enzyme secreted into the extracellular space that exhibits aspartic-type endopeptidase activity (GO:0004190) - Angiotensinogen (AGT, P01019): The substrate for renin, a hormone precursor protein - Angiotensin Converting Enzyme (ACE, P12821): Exhibits peptidyl-dipeptidase activity (GO:0008241) in the extracellular space - Angiotensin Type 1 Receptor (AGTR1, P30556): Located in the plasma membrane, exhibits angiotensin type I receptor activity (GO:0001596)
The pathway proceeds with Renin cleaving Angiotensinogen to produce Angiotensin I (implicit in the model), which is then processed by ACE to form Angiotensin II. Angiotensin II binds to the AGTR1 receptor, triggering the angiotensin-activated signaling pathway (GO:0038166).
This pathway is essential for angiotensin maturation (GO:0002003) and blood vessel diameter homeostasis (GO:0002034), processes that directly contribute to blood pressure regulation and cardiovascular function.
Feedback from AI on figure:
{"feedback":"The diagram effectively represents the renin-angiotensin pathway with clear labeling of each component and interaction. Different shapes and colors are used to distinguish between enzymes (circles), substrates (rounded rectangles), receptors (rectangles), and biological processes (orange rectangles), making the pathway easy to understand at a glance.\n\nThe pathway flow is clearly depicted with directional arrows showing the sequential processing from Angiotensinogen through Angiotensin I to Angiotensin II, and the subsequent receptor binding and signaling. All components from the GO-CAM model are accurately represented with their UniProt identifiers and GO terms.\n\nThe spatial organization effectively distinguishes between the extracellular space, plasma membrane, and intracellular space. The addition of a legend and pathway explanation enhances understanding of the diagram's elements and biological significance. Implicit components (like Angiotensin I) are appropriately marked with dashed lines to indicate they are not explicitly mentioned in the source GO-CAM but are necessary for understanding the pathway.\n\nThe diagram maintains a clean, professional appearance suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}