Figure: IL7-mediated signaling pathway (Human)¶
This diagram illustrates the IL7-mediated signaling pathway in humans. IL7 (P13232) in the extracellular space binds to its receptor complex consisting of IL7R (P16871) and IL2RG (P31785, co-receptor) on the plasma membrane. This binding activates the tyrosine kinases JAK1 (P23458) and JAK3 (P52333) on the cytoplasmic side of the plasma membrane. The activated JAKs phosphorylate transcription factors STAT5A (P42229) and STAT1 (P42224) in the cytoplasm, which then translocate to the nucleus where they function as DNA-binding transcription factors to regulate gene expression as part of the interleukin-7-mediated signaling pathway (GO:0038111).
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively captures the IL7-mediated signaling pathway with excellent scientific accuracy. The cellular compartmentalization (extracellular space, plasma membrane, cytoplasm, and nucleus) provides clear spatial context. Each protein is appropriately labeled with both its name and UniProt identifier, and color-coding helps distinguish different functional classes of molecules. The signal flow is logically represented with directional arrows showing the progression from IL7 binding through receptor activation, JAK phosphorylation, STAT activation, and nuclear translocation. The included legend enhances comprehension by explaining the symbols and line styles used in the diagram. The overall design is clean and professional, suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}