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Figure: TSLP-mediated signaling pathway (Human)

id: gomodel:6246724f00000763

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This diagram illustrates the TSLP-mediated signaling pathway in human cells.

The pathway begins with TSLP (Thymic stromal lymphopoietin, UniProtKB:Q969D9) in the extracellular space, which binds to its receptor complex on the plasma membrane. This receptor complex consists of IL7R (Interleukin-7 receptor, UniProtKB:P16871) and CRLF2 (Cytokine receptor-like factor 2, UniProtKB:Q9HC73).

Upon ligand binding, the receptor complex activates associated Janus kinases: JAK1 (UniProtKB:P23458) and JAK2 (UniProtKB:O60674) on the cytoplasmic side of the plasma membrane. These activated kinases phosphorylate the transcription factor STAT5A (Signal transducer and activator of transcription 5A, UniProtKB:P42229).

Once phosphorylated, STAT5A translocates to the nucleus where it functions as a DNA-binding transcription factor, regulating gene expression downstream of TSLP signaling.

This entire process is part of the cytokine-mediated signaling pathway (GO:0019221).

Feedback from AI on figure:

{"feedback":"The drawing is clear and accurately represents the TSLP-mediated signaling pathway as described. The diagram effectively uses colors and labels to distinguish different components like the cytokine, receptor complex, kinases, and transcription factors. The flow of the signaling pathway from TSLP binding to receptor activation, kinase phosphorylation, and transcription factor activity in the nucleus is logically depicted and easy to follow.","necessary_changes":null,"optional_changes":null}