Figure: hyaluronan biosynthetic process (Mouse)¶
The diagram illustrates the hyaluronan biosynthetic process in mouse cells, focusing on the key enzymes and their interactions.
Three hyaluronan synthases (Has1, Has2, and Has3) are embedded in the plasma membrane where they catalyze the synthesis of hyaluronan (HA). These enzymes function in the GO:0030213 hyaluronan biosynthetic process.
The ABC transporter Abcc5 (MGI:1351644) exports the synthesized hyaluronan from the cell to the extracellular space. All three hyaluronan synthases positively regulate this transport activity, as indicated by the dashed regulatory arrows.
In the extracellular space, the enzyme Cemip (MGI:2443629) demonstrates hyalurononglucosaminidase activity (GO:0004415), breaking down hyaluronan as part of the hyaluronan metabolic process (GO:0030212).
The solid arrows represent direct biochemical processes (synthesis and degradation), while dashed arrows indicate regulatory relationships between the enzymes. All these processes occur at the plasma membrane (GO:0005886) interface between the cytoplasm and extracellular space.
Feedback from AI on figure:
{"feedback":"The SVG diagram effectively captures the hyaluronan biosynthetic process in mouse cells with excellent clarity and scientific accuracy. The illustration faithfully represents the GO-CAM model while presenting it in a publication-ready format suitable for journals like Cell or Nature.\n\nStrengths:\n- Clear spatial organization showing the plasma membrane, cytoplasm, and extracellular space\n- Proper representation of the three hyaluronan synthases (Has1, Has2, Has3) embedded in the membrane\n- Accurate depiction of Abcc5 as an ABC transporter exporting hyaluronan\n- Inclusion of Cemip's role in hyaluronan degradation\n- Distinct arrow styles to differentiate between synthesis, regulation, and other processes\n- Well-designed legend explaining the components and processes\n- Text labels are properly sized and positioned for readability\n\nThe diagram successfully communicates the biological pathway while maintaining scientific accuracy. The use of different arrow styles helps clarify the relationships between components, and the overall layout provides a logical flow of information.","necessary_changes":null,"optional_changes":null}