Figure: Chondroitin sulfate biosynthetic process 1, chondroitin 6-sulfate proteoglycans (Mouse)¶
This figure illustrates the chondroitin sulfate biosynthetic process (GO:0030206) in mouse, occurring within the Golgi apparatus (GO:0005794). The pathway is organized into three main steps:
Step 1 (Chain Initiation): Csgalnact1 and Csgalnact2 enzymes catalyze the initial attachment of N-acetylgalactosamine to the substrate via glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity (GO:0047238).
Step 2 (Chain Polymerization): Chpf, Chpf2, Chsy1, and Chsy3 enzymes extend the polymer chain via N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity (GO:0050510), alternating between the addition of glucuronic acid and N-acetylgalactosamine residues.
Step 3 (Sulfation): The final modification involves sulfation by Chst3 and Chst7 enzymes through chondroitin 6-sulfotransferase activity (GO:0008459), yielding the completed chondroitin sulfate proteoglycan.
The arrows indicate the directional flow of the biosynthetic process, with enzyme activities represented by colored boxes according to the legend. All interactions shown are derived directly from the GO-CAM model, with no implicit details added.
Feedback from AI on figure:
{"feedback":"The drawing clearly illustrates the chondroitin sulfate biosynthetic process in the Golgi apparatus with a well-organized pathway. Arrows effectively indicate the direction and flow of the process with distinct steps labeled. Gene products and enzyme activities are clearly identified and categorized using a color-coded legend, aiding in clarity and understanding.","necessary_changes":null,"optional_changes":null}