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Figure: IL9-mediated signaling pathway (Human)

id: gomodel:626b20c100000025

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Figure Legend: IL-9-Mediated Signaling Pathway in Human Cells

The diagram illustrates the canonical IL-9 signaling pathway. IL-9 (orange circle) in the extracellular space binds to its receptor IL9R (blue rectangle) on the plasma membrane, which forms a functional receptor complex with the IL-2 receptor gamma chain (IL2RG, green rectangle). This receptor engagement activates receptor-associated Janus kinases: JAK1 (red polygon) and JAK3 (purple polygon) at the cytoplasmic side of the plasma membrane.

The activated JAKs phosphorylate (indicated by yellow dots) cytoplasmic STAT transcription factors: STAT1 (brown), STAT3 (pink), and STAT5A (gray). Upon phosphorylation, these STATs translocate to the nucleus (indicated by dashed arrows) where they bind to DNA to regulate gene expression of target genes.

This pathway plays crucial roles in immune cell development and function, particularly in T cell biology, and has implications in various inflammatory and allergic conditions.

Feedback from AI on figure:

{"feedback":"The drawing effectively illustrates the IL-9 mediated signaling pathway with proper compartmentalization of cellular components. The pathway flow is clear, showing IL-9 binding to its receptor complex (IL9R/IL2RG), activation of JAK1/JAK3 kinases, phosphorylation of STAT transcription factors, and their subsequent translocation to the nucleus for gene regulation.\n\nThe distinct shapes and colors for different proteins help distinguish their roles, with receptors as rounded rectangles, kinases as polygons, and transcription factors as circles. The phosphorylation indicators (yellow dots) effectively show post-translational modification. The compartmentalization of cellular spaces (extracellular, plasma membrane, cytoplasm, and nucleus) provides clear spatial context for the signaling events.\n\nFont sizes have been increased for better readability, and the pathway elements are well-arranged to show the sequence of signaling events from IL-9 binding through to gene regulation.","necessary_changes":null,"optional_changes":null}