Figure: Regulation of gluconeogenesis by TOX4 (Mouse)ΒΆ
This diagram illustrates the regulation of gluconeogenesis by TOX4 in mouse hepatocytes. In the nucleus, transcription factors TOX4 (red), FOXO1 (blue), and CREB1 (green) bind to chromatin and positively regulate each other's activity. Together, they promote the transcription of genes encoding G6PC1 and PCK1, which are enzymes located in the endoplasmic reticulum. G6PC1 (glucose-6-phosphatase) and PCK1 (phosphoenolpyruvate carboxykinase) are key enzymes in the gluconeogenesis pathway, which produces glucose from non-carbohydrate substrates. This pathway illustration is based on experimental evidence from mouse studies and shows how these factors coordinate to regulate glucose production in liver cells.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the regulation of gluconeogenesis by TOX4 in mouse liver cells, featuring a clear cellular organization with distinct nuclear and endoplasmic reticulum compartments. The transcription factors (TOX4, FOXO1, and CREB1) are well-represented in the nucleus with their interactions with chromatin clearly shown. The enzymatic components (G6PC1 and PCK1) are appropriately placed in the endoplasmic reticulum.\n\nThe colored arrows and text labels enhance the visualization of regulatory relationships, and the background blocks behind regulatory text significantly improve readability. The comprehensive legend aids in understanding the different components of the pathway, and the title clearly identifies the biological process being depicted.\n\nThe diagram successfully combines molecular detail with cellular context, creating a publication-quality figure suitable for journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}