Figure: IL10-mediated signaling pathway (Human)¶
The diagram illustrates the IL10-mediated signaling pathway in human cells. IL10 cytokine in the extracellular space binds to IL10RA receptor on the plasma membrane, which forms a complex with IL10RB coreceptor. This receptor complex activation triggers the associated protein tyrosine kinases JAK1 and TYK2 on the cytoplasmic side of the membrane. These kinases then phosphorylate and activate STAT3, which translocates to the nucleus where it functions as a DNA-binding transcription factor to regulate gene expression. Different arrow styles indicate different types of interactions: binding, activation, phosphorylation, and translocation.
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively visualizes the IL10-mediated signaling cascade from extracellular cytokine binding through nuclear transcription factor activation. The use of distinct shapes and colors for different proteins makes each component easily identifiable, while the gradient arrows provide immediate visual cues about the type of interaction occurring at each step. The step-by-step descriptions enhance understanding without cluttering the figure, making it suitable for publication in high-impact journals like Cell or Nature. The cellular compartments are clearly delineated, and the overall flow of the pathway is intuitive to follow.","necessary_changes":null,"optional_changes":null}