Figure: IL11-mediated signaling pathway (Human)¶
This illustration depicts the IL11-mediated signaling pathway in human cells. The pathway begins in the extracellular space where IL11 cytokine (P20809) binds to its receptor IL11RA (Q14626) on the plasma membrane. This binding activates IL6ST (P40189), a coreceptor also located on the plasma membrane. IL6ST activation then triggers JAK1 (P23458), a protein tyrosine kinase positioned on the cytoplasmic side of the plasma membrane. Activated JAK1 subsequently phosphorylates STAT3 (P40763), which then translocates from the cytoplasm to the nucleus where it functions as a DNA-binding transcription factor, regulating gene expression associated with the IL11 signaling pathway.
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the IL11-mediated signaling pathway with clear compartmentalization of cellular components. The use of distinct shapes and colors helps distinguish different proteins in the pathway, while directional arrows clearly show the sequence of activation from IL11 binding to STAT3 nuclear translocation and DNA binding. The addition of a specific label for the STAT3 translocation process enhances clarity, and the improved font sizes and consistent positioning of labels make the diagram easy to read and interpret. The comprehensive legend provides the necessary context for understanding the biological components and processes depicted.","necessary_changes":null,"optional_changes":null}