Figure: IL12-mediated signaling pathway (Human)¶
The figure illustrates the IL12-mediated signaling pathway in humans. In the extracellular space, IL12A and IL12B subunits bind to form the active IL12 cytokine. IL12 then binds to its receptors IL12RB1 and IL12RB2 on the plasma membrane. This receptor activation triggers the associated tyrosine kinases TYK2 and JAK2 located on the cytoplasmic side of the plasma membrane. The activated kinases phosphorylate STAT4, which then translocates to the nucleus to function as a transcription factor. This pathway is crucial for T-helper 1 cell differentiation and immune response regulation.
Feedback from AI on figure:
{"feedback":"The drawing clearly depicts the IL12-mediated signaling pathway with appropriate cellular compartmentalization and molecular interactions. All key components from the GO-CAM model are included: the extracellular IL12A and IL12B cytokines and their complex formation, the membrane receptors IL12RB1 and IL12RB2, the cytoplasmic kinases TYK2 and JAK2, and the transcription factor STAT4 and its nuclear translocation. The color-coding, labeling, and legend effectively distinguish between different molecular types. The addition of interaction labels clarifies the signaling mechanism.","necessary_changes":null,"optional_changes":null}