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Figure: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process (Mouse)

id: gomodel:627d95ee00000044

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This diagram illustrates the 3'-phosphoadenosine 5'-phosphosulfate (PAPS) biosynthetic pathway in mice.

Sulfate ions (SO₄²⁻) are transported from the extracellular space into the cytosol by the membrane transporters Slc26a1 and Slc26a2. In the cytosol, Papss1 catalyzes the first step of PAPS synthesis through its sulfate adenylyltransferase activity, converting sulfate and ATP to adenosine 5'-phosphosulfate (APS). Then, Papss2 catalyzes the second step through its adenylylsulfate kinase activity, converting APS and ATP to PAPS. Finally, PAPS is transported from the cytosol into the Golgi apparatus by the transporters Slc35b2 and Slc35b3 located on the Golgi membrane.

The diagram is color-coded: yellow for sulfate ions, green for ATP, cyan for APS, magenta for PAPS, pink for transporters, and blue for enzymes. The reactions flow from the extracellular environment through the cytosol and into the Golgi, representing the complete PAPS biosynthetic process as described in the GO-CAM model.

Feedback from AI on figure:

{"feedback":"This SVG drawing effectively illustrates the 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process in mice, following journal-quality figure standards. The diagram clearly separates cellular compartments (extracellular region, plasma membrane, cytosol, and Golgi apparatus) with appropriate visual styling and labeling. The pathway is accurately represented with properly labeled components, showing sulfate transport across the plasma membrane by Slc26a1 and Slc26a2, followed by the two-step enzymatic process catalyzed by Papss1 and Papss2 in the cytosol, and finally PAPS transport to the Golgi by Slc35b2 and Slc35b3. The diagram uses professional color coding with a clear legend, and includes annotations for enzyme functions directly on the figure. The cellular components, molecular interactions, and transport events are all faithfully rendered according to the GO-CAM data.","necessary_changes":null,"optional_changes":null}