Figure: Heparan sulfate proteoglycan catabolic process (Mouse)¶
This diagram illustrates the heparan sulfate proteoglycan catabolic process in mice, depicting the sequential enzymatic breakdown pathway. At the plasma membrane, Syndecan-1 (Sdc1) functions as a cargo receptor that interacts with Heparanase (Hpse) acting as a cargo receptor ligand, initiating receptor-mediated endocytosis. Within the lysosomal lumen, Cathepsin L (Ctsl) activates Heparanase, which then begins the degradation process. The sequential enzymatic breakdown involves: L-iduronidase (Idua), N-sulfoglucosamine sulfohydrolase (Sgsh), Heparan-alpha-glucosaminide N-acetyltransferase (Hgsnat), Alpha-N-acetylglucosaminidase (Naglu), Iduronate-2-sulfatase (Ids), a second application of L-iduronidase (Idua), Beta-glucuronidase (Gusb), and finally Beta-galactosidase (Glb1). Each enzyme is shown with its specific molecular function and GO term annotation. The diagram represents the complete GO-CAM model gomodel:627d95ee00000275 of the heparan sulfate proteoglycan catabolic process (GO:0030200).
Feedback from AI on figure:
{"feedback":"The diagram effectively represents the heparan sulfate proteoglycan catabolic pathway in mice, providing a clear visualization that would be suitable for publication in journals like Cell or Nature. The hierarchical organization shows both subcellular localization and sequential enzymatic activities, making the complex process easy to understand. All gene products from the GO-CAM are included, with proper representation of their molecular functions and cellular locations.","necessary_changes":null,"optional_changes":null}