Figure: Regulation of CGAS activity by ZDHHC18 (Human)¶
This figure illustrates the regulation of cGAS activity by ZDHHC18 in human cells. ZDHHC18 (UniProtKB:Q9NUE0) is localized in the Golgi apparatus where it functions as a protein-cysteine S-palmitoyltransferase (GO:0019706). ZDHHC18 negatively regulates (RO:0002630) the activity of cGAS (UniProtKB:Q8N884) in the cytosol through palmitoylation. cGAS exhibits double-stranded DNA binding activity (GO:0003690) and molecular condensate scaffold activity (GO:0140693) as part of the cGAS/STING signaling pathway (GO:0140896). This negative regulation forms part of the process that controls the cGAS/STING signaling pathway (GO:0160049).
Feedback from AI on figure:
{"feedback":"This pathway diagram effectively captures the key elements of the GO-CAM model, showing how ZDHHC18 negatively regulates cGAS activity through palmitoylation. The cellular compartmentalization is well-represented, with ZDHHC18 in the Golgi apparatus and cGAS in the cytosol. The molecular functions are clearly depicted, including cGAS binding to double-stranded DNA and its role in forming molecular condensates. The diagram style is suitable for a scientific publication, with clear labels, appropriate use of colors, and a comprehensive legend.","necessary_changes":null,"optional_changes":"Consider adding some text explaining the biological significance of this pathway in the context of innate immunity, or a note indicating that cGAS activation leads to downstream signaling events that were not included in the original GO-CAM model."}