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Figure: Chondroitin sulfate catabolic process (Mouse)

id: gomodel:627d95ee00000955

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This diagram depicts the chondroitin sulfate catabolic process (GO:0030207) in mouse lysosomes. The pathway involves multiple enzymes that sequentially break down chondroitin sulfate:

  1. Initial sulfate removal by N-acetylgalactosamine-6-sulfatase (Galns) and N-acetylgalactosamine-4-sulfatase (Arsb)
  2. Chain hydrolysis by three chondroitin hydrolases (Hyal1, Hyal3, and Hyal4)
  3. Removal of glucuronic acid by beta-glucuronidase (Gusb)
  4. Final degradation by hexosaminidase (Hexb)

All enzymatic reactions occur within the lysosomal compartment (GO:0005764). Arrows indicate the flow of the pathway and causal relationships between enzyme activities.

Feedback from AI on figure:

{"feedback":"This drawing effectively illustrates the chondroitin sulfate catabolic pathway in mouse lysosomes as described in the GO-CAM model. The diagram has several strengths: 1) Clear organization of enzymes in their sequential order, making the pathway flow easy to follow; 2) Appropriate compartmentalization within the lysosome, correctly representing the cellular location; 3) Detailed labeling of each enzyme with both its gene name and molecular function; 4) Effective use of color coding to distinguish between different components (enzymes, substrate, products); 5) Addition of a brief description and step-by-step breakdown that enhances understanding. The drawing maintains scientific accuracy while using artistic elements to create a figure suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}