Figure: Il17A mediated signaling pathway (Human)¶
This diagram depicts the IL-17A mediated signaling pathway in humans with SARS-CoV-2 ORF8 perturbation. In the extracellular space, IL-17A (shown as a pink circle) and SARS-CoV-2 ORF8 (red circle) interact with the IL-17RA/IL-17RC receptor complex (blue rectangles) on the plasma membrane. This interaction triggers recruitment of TRAF3IP2/ACT1 (green triangle) at the cytoplasmic side of the plasma membrane, which then ubiquitinates TRAF6 (green triangle). TRAF6 subsequently ubiquitinates MAP3K7/TAK1 (orange oval), a kinase that phosphorylates downstream targets. The pathway is organized across three distinct cellular compartments: extracellular space (GO:0005615), plasma membrane (GO:0005886), and cytoplasm (GO:0005737).
Feedback from AI on figure:
{"feedback":"The diagram effectively illustrates the IL-17A mediated signaling pathway with SARS-CoV-2 ORF8 perturbation. The clear organization into cellular compartments (extracellular space, plasma membrane, cytoplasm) helps convey the biological context of each interaction. The use of different shapes and colors for different molecule types (cytokines, viral proteins, receptors, adaptors, kinases) enhances visual clarity, while the labeled arrows specify the nature of each interaction (activates, perturbs, recruits, ubiquitinates, phosphorylates). The inclusion of both formal gene names and common aliases (e.g., TRAF3IP2/ACT1, MAP3K7/TAK1) increases accessibility for different audiences. All text is now properly positioned and sized for readability.","necessary_changes":null,"optional_changes":null}