Figure: Activation of PARP1 activity by HPF1 during DNA repair (Human)¶
This diagram illustrates the PARP1 activation pathway by HPF1 during DNA repair in humans. The pathway begins when DNA damage occurs, triggering PARP1 binding to the damaged DNA site. PARP1 then forms homodimers at the damage site. HPF1 acts as an adaptor, enabling PARP1's NAD+-protein-serine ADP-ribosyltransferase activity. This activity ultimately leads to PARP1 performing poly-ADP-ribosylation during DNA repair. The diagram shows how these molecular functions are part of broader biological processes: DNA damage response (GO:0006974) and DNA repair (GO:0006281). All components and interactions are based on the GO-CAM model, with relevant GO terms indicated for each activity.
Feedback from AI on figure:
{"feedback":"This illustration effectively captures the GO-CAM model depicting PARP1 activation by HPF1 during DNA repair. The drawing strengths include: (1) Clear color-coding that distinguishes between different proteins (PARP1, HPF1) and biological processes (DNA damage response, DNA repair); (2) Logical flow of events with labeled transitions showing activation relationships between steps; (3) Precise labeling of each molecular function with appropriate GO terms; (4) Effective visualization of the nuclear context and DNA damage site; (5) Professional journal-quality presentation with an informative legend and consistent visual style. The diagram successfully represents all key components from the GO-CAM model while maintaining visual clarity, making it suitable for publication in journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}