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Figure: Regulation of Parp1 activity by Cgas, Setd7 and Riox1 (Mouse)

id: gomodel:627d95ee00001988

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The diagram depicts a pathway showing the regulation of Parp1 activity by Cgas, Setd7, and Riox1 in mouse cells. At the center is the nucleus containing a DNA damage site where Parp1 functions in DNA repair by adding poly-ADP-ribose (PAR) modifications to proteins. The regulatory pathway includes:

  1. Setd7: A protein-lysine N-methyltransferase (GO:0016279) that methylates target proteins
  2. Sgf29: A methylation-dependent protein binding protein (GO:0140034) that recognizes methylated targets and negatively regulates Cgas
  3. Riox1: A 2-oxoglutarate-dependent dioxygenase (GO:0016706) that demethylates proteins and positively regulates Cgas
  4. Cgas: A protein with poly-ADP-ribose modification-dependent binding capability (GO:0160004) that negatively regulates Parp1's DNA repair activity

The diagram shows regulatory relationships with dashed arrows (green for positive regulation, red for negative regulation) and direct interactions with solid black arrows. The PAR modification produced by Parp1 is represented by a purple wavy line.

Feedback from AI on figure:

{"feedback":"This diagram effectively illustrates the regulation of Parp1 activity through a network of protein interactions involving Cgas, Setd7, and Riox1. The visual representation is clear and follows scientific journal figure standards with distinct protein shapes, color-coding, and clearly marked regulatory relationships. The diagram maintains scientific accuracy while using appropriate visual elements to represent cellular compartments, protein activities, and regulatory connections.\n\nThe improvements from the initial version include:\n1. Enhanced readability with larger fonts and bolder lines\n2. More detailed legend explaining the molecular functions and modification types\n3. Better organization of elements with clear directional flow\n4. Improved labeling of GO terms and relationship ontologies\n\nThe diagram successfully balances scientific detail with visual clarity, making it suitable for publication in high-impact journals like Cell or Nature.","necessary_changes":null,"optional_changes":null}