Figure: Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human)¶
This figure illustrates the pathway of Mono-ADP-ribosylation of ribosome subunits by PARP16 in human cells, as described in the GO-CAM model (gomodel:62900b6400000022).
PARP16 (UniProtKB:Q8N5Y8) exhibits NAD+-protein-glutamate ADP-ribosyltransferase activity (GO:0140807) and targets two ribosomal proteins: RPS6 (UniProtKB:P62753) and RPL24 (UniProtKB:P83731) in the cytosolic ribosome (GO:0022626). Both ribosomal proteins function as structural constituents of the ribosome (GO:0003735) and participate in cytoplasmic translation (GO:0002181).
NMNAT2 (UniProtKB:Q9BZQ4) acts as a protein ADP-ribosyltransferase-substrate adaptor (GO:0140768) that positively regulates PARP16's ADP-ribosyltransferase activity. When PARP16 ADP-ribosylates RPS6 and RPL24, it negatively regulates cytoplasmic translation (GO:2000766).
Note: NAD+ is not explicitly mentioned in the source GO-CAM but is included in the figure as it is the substrate for ADP-ribosylation by PARP16.
Feedback from AI on figure:
{"feedback":"The SVG drawing effectively represents the Mono-ADP-ribosylation pathway involving PARP16 in human cells. The diagram clearly illustrates how PARP16 negatively regulates cytoplasmic translation by ADP-ribosylating the ribosomal proteins RPS6 and RPL24, and how NMNAT2 positively regulates PARP16.\n\nThe improved version features:\n1. Enhanced readability with larger fonts and bold text for key elements\n2. Color-coded arrows with matching arrowheads that distinguish different types of regulation\n3. A comprehensive legend explaining all symbols and connections\n4. Clear labeling of all proteins with their UniProt IDs and GO terms\n5. Professional layout resembling figures in scientific journals like Cell or Nature\n\nThe diagram successfully balances scientific accuracy with visual clarity, making the complex molecular pathway accessible while maintaining fidelity to the GO-CAM model.","necessary_changes":null,"optional_changes":null}